Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other allergies. Learn about side effects, interactions and indications. The generic version of Benadryl is called diphenhydramine. A generic drug is an exact copy of the active drug in a brand-name medication and considered as safe and effective as the original drug. Many allergy tablets labeled as comparable products list diphenhydramine HCl as the active ingredient. That name is what you’ll typically see on the Drug Facts panel for the generic version. Match the strength and dosage form (tablet, capsule, or liquid gel) to what you prefer. Benadryl USA shoppers choose fast, familiar allergy relief for sneezing, itching, and watery eyes. Benadryl is an antihistamine that helps block histamine responses from everyday allergens. Relieves sneezing, runny nose, itchy throat & watery eyes. Indoor & outdoor allergy antihistamine. Adults & 12+. Diphenhydramine, also known by the brand name Benadryl, is an over-the-counter antihistamine used to relieve allergy or common cold symptoms in adults and children. First-generation antihistamines, like Benadryl (diphenhydramine) and Chlor-Trimeton (chlorpheniramine), often cause sedation. This can include drowsiness, fatigue, and reduced alertness or concentration. Find patient medical information for Diphenhydramine (Benadryl, Unisom, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Discover the power of generic Benadryl to provide comprehensive allergy symptom relief. Explore large quantity options for long-lasting, affordable solutions. Diphenhydramine, or Diphenylhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. Although generally considered sedating, diphenhydramine can cause paradoxical central nervous system stimulation in some individuals, particularly at higher doses.